Andrew Z. Fire - Nobel Lecture

Gene silencing by double-stranded RNA (Nobel Lecture).

Andrew Zachary Fire (1959- )

Andrew Zachary Fire is a professor at Stanford University [5] and Nobel Laureate. Fire worked at the Carnegie Institution of Washington?s Department of Embryology with colleague Craig Mello, where they discovered that RNA molecules could be used to turn off or knock out the expression of genes [6]. Fire and Mello called the process RNA interference [7] (RNAi), and won the Nobel Prize in Physiol...

Evaluation of a Kernel Function for Recognizing microRNAs

MicroRNAs were recently discovered, in 1993, when it was first reported that a small RNA in Caenorhabditis elegans, called lin-4, was responsible for regulating the expression of the lin-14 gene through direct interaction with its messenger RNA [8, 13]. A few years later, Andrew Z. Fire and Craig C. Mello published a paper in Nature [3] describing how tiny snippets of RNA can destroy the gene’s...

The Nobel Prize in Physiology or Medicine for 2006 jointly to Andrew Fire and Craig Mello

An adult human being has about 100 000 billion cells. The nucleus of each cell carries all our genetic material: a total of two meters of DNA containing some 30 000 genes. When genes are expressed (activated), genetic information is copied from DNA to messenger molecules, messenger RNA (mRNA), which then orchestrate formation of proteins. Proteins are involved in the life processes of all organ...

RNA Interference: Big Applause for Silencing in Stockholm

Eight years ago, Craig Mello, Andrew Fire, and their coworkers provided the first demonstration that double-stranded RNA (dsRNA) triggers the gene-silencing technique that we now call RNA interference (RNAi). For this landmark discovery, Mello and Fire are honored with this year's Nobel Prize in Physiology or Medicine.